Publications

(selected publications from a total of 65)

64. Velez B, Walsh RM Jr., Rawson S, Razi A, Adams L, Fermin Perez E, Jiao F, Blickling M, Rajakumar T, Fung D, Huang L, and Hanna J.  Mechanism of Autocatalytic Activation During Proteasome Assembly. Nat Struct Mol Biol. 2024. Epub. April 10. 2024

Click here to read the paper. 

63. Adolf F, Du J, Goodall EA, Walsh RM Jr., Rawson S, von Gronau S, Harper JW, Hanna J*, and Schulman B*. Visualizing Chaperone-Mediated Multistep Assembly of the Human 20S Proteasome. Nat Struct Mol Biol. 2024. Epub. April 10, 2024

61. Velez B, Razi A, Hubbard RD, Walsh R, Rawson S, Tian G, Finley D, and Hanna J. Rational Design of Proteasome Inhibitors Based on the Structure of the Endogenous Inhibitor PI31/Fub1.  PNAS. 2023. 120(51):e2308417120.

Click here to read the Mass General Brigham press release

59. Walsh RM Jr., Rawson S, Schnell HM, Velez B, Rajakumar T, and Hanna J. Structure of the Preholoproteasome Reveals Late Steps in Proteasome Core Particle Biogenesis. Nat Struct Mol Biol. 2023. 30(10):1516-1524.

Click here to read the paper.

49. Schnell HM and Hanna J. DUB-le Vision: Snapshots of the Proteasome During Substrate Processing. Trends in Biochem. Sci. 2022. 47(11):903-905

48. Shaun Rawson*, Richard M. Walsh, Jr.*, Benjamin Velez, Helena M. Schnell, Fenglong Jiao, Marie Blickling, Jessie Ang, Meera K. Bhanu, Lan Huang, and John Hanna. (2022). Yeast PI31 Inhibits the Proteasome by a Direct Multisite Mechanism. Nat Struct Mol Biol. 29(8):791-800

46. Helena Maria Schnell, Jessie Ang, Richard M. Walsh Jr., Shaun Rawson, Yagmur Micoogullari, and John Hanna. (2022). Mechanism of Proteasome Gate Modulation by the Assembly Chaperones Pba1 and Pba2. J. Biol. Chem. 298(5):101906.

Read the paper here: https://doi.org/10.1016/j.jbc.2022.101906

45. Helena Maria Schnell, Richard M. Walsh Jr., Shaun Rawson, and John Hanna. (2022). Chaperone-Mediated Assembly of the Proteasome Core Particle–Recent Developments and Structural Insights. J. Cell. Sci. 135(8):jcs259622

Click here to read the paper.

42. Helena Maria Schnell, Richard M. Walsh Jr., Shaun Rawson, Mandeep Kaur, Meera K. Bhanu, Geng Tian, Miguel A. Prado, Angel Guerra-Moreno, Joao A. Paulo, Steven P.  Gygi, Jeroen Roelofs, Daniel Finley, and John Hanna. (2021). Structures of Chaperone-Associated Assembly Intermediates Reveal Coordinated Mechanisms of Proteasome Biogenesis. Nat Struct Mol Biol. 2021. 28(5): 418-425.

Read the paper here: https://rdcu.be/ciybl

41. Helena Maria Schnell, Marco Jochem, Yagmur Micoogullari, Claire Louise Riggs, Pavel Ivanov, Hendrik Welsch, Rini Ravindran, Paul Anderson, Lucy Christina Robinson, Kelly Tatchell, and John Hanna. (2021). Reg1 and Snf1 Regulate Stress-Induced Relocalization of Protein Phosphatase-1 to Cytoplasmic Granules. FEBS J. 288(16): 4833-4848.

36. Yagmur Micoogullari, Sankha S Basu, Jessie Ang, Nina Weisshaar, Nicholas D Schmitt, Walid M Abdelmoula, Begona Lopez, Jeffrey N Agar, Nathalie Agar, and John Hanna. (2020). Dysregulation of very long chain fatty acid metabolism causes membrane saturation and induction of the unfolded protein response. Mol Biol Cell.  31(1):7-17

35. Angel Guerra-Moreno, Miguel A Prado, Jessie Ang, Helena M Schnell, Yagmur Micoogullari, Joao A Paulo, Daniel Finley, Steven P Gygi, and John Hanna. (2019). Thiol-Based Direct Threat Sensing by the Stress-Activated Protein Kinase Hog1. Science Signaling.  Nov 26;12(609). 

32. Angel Guerra-Moreno, Jessie Ang, Hendrik Welsch, Marco Jochem, and John Hanna. (2019). Regulation of the Unfolded Protein Response in Yeast by Oxidative Stress.  FEBS Letters. 593: 1080-1088

31. Marco Jochem, Lukas Ende, Marta Isasa, Jessie Ang, Helena Schnell, Angel Guerra-Moreno, Yagmur Micoogullari, Steven P. Gygi, and John Hanna. (2019). Targeted Degradation of Glucose Transporters Protects Against Arsenic Toxicity. Mol. Cell. Biol. 39 (10).

29. John Hanna, Angel Guerra-Moreno, Jessie Ang, and Yagmur Micoogullari. (2018). Protein Degradation and the Pathologic Basis of Disease. Am. J Pathology. 189(1): 94-103.

28. Angel Guerra-Moreno and John Hanna.  (2017). Induction of Proteotoxic Stress by the Mycotoxin Patulin. Toxicol Lett. 276: 85-91.

27. Nina Weisshaar, Hendrik Welsch, Angel Guerra-Moreno, and John Hanna. (2017). Phospholipase Lpl1 Links Lipid Droplet Function with Quality Control Protein Degradation. Mol. Biol. Cell. 28 :716-725.

26. Zhen-Yu J. Sun, Meera K. Bhanu, Martin G. Allan, Haribabu Arthanari, Gerhard Wagner, and John Hanna. (2016). Solution Structure of the Cuz1 AN1 Zinc Finger Domain: An Exposed LDFLP Motif Defines a Subfamily of AN1 Proteins. PLOS One. 11(9):e0163660.

24. Angel Guerra-Moreno and  and John Hanna. (2016). Tmc1 is a Dynamically Regulated Effector of the Rpn4 Proteotoxic Stress Response. J Biol Chem.   291: 14788-95.

23. Angel Guerra-Moreno, Marta  Isasa, Meera K. Bhanu, David P. Waterman, VV Eapen, Steven P. Gygi, and John Hanna. (2015). Proteomic Analysis Identifies Ribosome Reduction as an Effective Proteotoxic Stress Response. J Biol Chem. 290: 29695-29706.

21. John Hanna*, David Waterman, Marta Isasa, Suzanne Elsasser, Yuan Shi, Steven Gygi, and Daniel Finley. (2014). Cuz1/Ynl155w, a Zinc-Dependent Ubiquitin Binding Protein, Protects Cells from Metalloid-Induced Proteotoxicity. J Biol Chem.  289, 1876-85.

*Corresponding author.

18. John Hanna*, David Waterman, Monica Boselli, and Daniel Finley. (2012). Spg5 protein regulates the proteasome in quiescence. J Biol Chem. 287, 34400-9.

*Co-lead author & co-corresponding author

17. Chen PC, Bhattacharyya BJ, John Hanna, Minkel H, Wilson JA, Finley D, Miller RJ, Wilson SM. (2011). Ubiquitin homeostasis is critical for synaptic development and function. J Neurosci. 31, 17505-13.

14. Byung-Hoon Lee, Min Jae Lee, Soyeon Park, Dong-Chan Oh, Suzanne Elsasser, Ping-Chung Chen, Carlos Gartner, Nevena Dimova, John Hanna, Steven P. Gygi, Scott M. Wilson, Randall W. King, and Daniel Finley. (2010). Enhancement of proteasome activity by a small molecule inhibitor of Usp14. Nature. 467, 179-184.

[See Comment in Nat Rev Mol Cel Biol. (2010) 11, 754-755]

13. Min Jae Lee, Byung-Hoon Lee, John Hanna, Randall W. King, and Daniel Finley. (2010). Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Mol. Cell. Proteomics. 10, R110.

12. John Hanna and Daniel Finley. (2007) A proteasome for all occasions. FEBS Lett. 581, 2854.

11. John Hanna, Alice Meides, Dan P. Zhang, and Daniel Finley. (2007) A ubiquitin stress response alters proteasome composition. Cell. 129, 747-759.

[See comment in Cell (2007) 129, 659-662]
[See comment in Nature Rev. Mol. Cell Biol. (2007) 8, 511]
[See comment in Trends In Cell Biol. (2007) 17, 419-421]

10. Bernat Crosas, John Hanna, Donald S. Kirkpatrick, Dan P. Zhang, Yoshiko Tone, Nathaniel A. Hathaway, Christa Buecker, David S. Leggett, Marion Schmidt, Randall W. King, Steven P. Gygi, and Daniel Finley. (2006) Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities. Cell. 127, 1401-1413.

[See comment in Trends In Cell Biol. (2007) 17, 419-421]

9. John Hanna, Nathaniel A. Hathaway, Yoshiko Tone, Bernat Crosas, Suzanne Elsasser, Donald S. Kirkpatrick, David S. Leggett, Steven P. Gygi, Randall W. King, and Daniel Finley D. (2006) Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation. Cell. 127, 99-111.

[See comment in J. Cell Biol. (2006) 175, 367]
[See comment in Trends In Cell Biol. (2007) 17, 419-421]

8. Donald S. Kirkpatrick, Nathaniel A. Hathaway, John Hanna, Suzanne Elsasser, John Rush, Daniel Finley, Randall W. King, and Steven P. Gygi. (2006) Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology. Nat Cell Biol. 8, 700-10.

7. Marion Schmidt, John Hanna, Suzanne Elsasser, and Daniel Finley. (2005) Proteasome-Associated Proteins:  Regulation of a Proteolytic Machine. Biol. Chem. 386: 725-737.

6. Suzanne Elsasser, Chandler-Militello, Britta Mueller, John Hanna, and Daniel Finley. (2004) Rad23 and Rpn10 serve as alternate ubiquitin receptors for the proteasome. J. Biol. Chem. 279, 26817-26822.

5. John Hanna, David S. Leggett, and Daniel Finley. (2003) Ubiquitin depletion as a key mediator of toxicity by translational inhibitors.  Mol. Cell. Biol. 23, 9251-9261.

3. David Leggett, John Hanna, Anna Borodovsky, Bernat Crosas,  Marion Schmidt, Rohan Baker, Thomas Walz, Hidde Ploegh, and Dan Finley. (2002) Multiple associated proteins regulate proteasome structure and function. Mol. Cell. 10, 495-507.

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